Tear Lipocalin: structure and Function
نویسندگان
چکیده
منابع مشابه
Tear lipocalin: structure, function and molecular mechanisms of action.
Human tear lipocalin (TL), or von Ebner's gland protein, accounts for about 15-33% of the protein in tears. I-4 TL has been identified in lacrimal gland, von Ebner' s gland, prostate, nasal and tracheal mucosa and skin.512 TL was recognized as a member of the lipocalin family when its primary sequence was determined.7.I3 .14 Lipocalins form a functionally diverse group of proteins with extremel...
متن کاملLipocalin structure and function.
The lipocalins are a family of proteins the common function of which is to bind small hydrophobic substances. Although the amino-acid sequence similarity among the members of the family is low, there are two regions where the sequences are conserved. These are GXW and TDY (where X is usually acidic) [ 11. X-ray crystallography of several members of the family revealed that they exhibit a high d...
متن کاملThe lipocalin protein family: structure and function.
The lipocalin protein family is a large group of small extracellular proteins. The family demonstrates great diversity at the sequence level; however, most lipocalins share three characteristic conserved sequence motifs, the kernel lipocalins, while a group of more divergent family members, the outlier lipocalins, share only one. Belying this sequence dissimilarity, lipocalin crystal structures...
متن کاملInteraction of tear lipocalin with lysozyme and lactoferrin.
The interaction of human tear lipocalin with lysozyme and lactoferrin was studied by electron paramagnetic resonance (EPR) spectroscopy. TL mutants I98C and F99C were spin labeled with MTSL and its derivative. The spectra demonstrated that at sites C98 and C99 the mobility of the nitroxides was reduced in the presence of lysozyme, lactoferrin, but not albumin. The reduced mobility was manifeste...
متن کاملTear lipocalin and the eye's front line of defence.
Complex mechanisms are involved in mucosal defence at the air/epithelium interface. There are apparently two lines of protection. The first, which we are interested in here, prevents colonisation by micro-organisms on and through the epithelium. It is a non-inflammatory process, mainly mediated by (i) well known defence factors such as lysozyme and lactoferrin, (ii) specific secretory immunoglo...
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ژورنال
عنوان ژورنال: The Ocular Surface
سال: 2011
ISSN: 1542-0124
DOI: 10.1016/s1542-0124(11)70022-2